diff --git a/pkgs/applications/graphics/exrtools/default.nix b/pkgs/applications/graphics/exrtools/default.nix
index 7980d09fed12..01af81d4de74 100644
--- a/pkgs/applications/graphics/exrtools/default.nix
+++ b/pkgs/applications/graphics/exrtools/default.nix
@@ -9,6 +9,11 @@ stdenv.mkDerivation rec {
     sha256 = "0jpkskqs1yjiighab4s91jy0c0qxcscwadfn94xy2mm2bx2qwp4z";
   };
 
+  preConfigure = ''
+    CC=${stdenv.cc.targetPrefix}cc
+    CXX=${stdenv.cc.targetPrefix}c++
+  '';
+
   nativeBuildInputs = [ pkgconfig ];
   buildInputs = [ stdenv openexr libpng12 libjpeg ];
 
diff --git a/pkgs/applications/misc/kiwix/default.nix b/pkgs/applications/misc/kiwix/default.nix
index c37d26f3dbcc..cfba3a0c83d1 100644
--- a/pkgs/applications/misc/kiwix/default.nix
+++ b/pkgs/applications/misc/kiwix/default.nix
@@ -81,6 +81,11 @@ stdenv.mkDerivation rec {
     cd ../../..
   '';
 
+  preConfigure = ''
+    CC=${stdenv.cc.targetPrefix}cc
+    CXX=${stdenv.cc.targetPrefix}c++
+  '';
+
   configureFlags = [
     "--disable-static"
     "--disable-staticbins"
diff --git a/pkgs/applications/science/logic/aiger/default.nix b/pkgs/applications/science/logic/aiger/default.nix
index 03524fc6b222..a03e777a033e 100644
--- a/pkgs/applications/science/logic/aiger/default.nix
+++ b/pkgs/applications/science/logic/aiger/default.nix
@@ -12,6 +12,9 @@ stdenv.mkDerivation rec {
   enableParallelBuilding = true;
 
   configurePhase = ''
+    CC=${stdenv.cc.targetPrefix}cc
+    CXX=${stdenv.cc.targetPrefix}c++
+
     # Set up picosat, so we can build 'aigbmc'
     mkdir ../picosat
     ln -s ${picosat}/include/picosat/picosat.h ../picosat/picosat.h
diff --git a/pkgs/applications/science/logic/verit/default.nix b/pkgs/applications/science/logic/verit/default.nix
index ca3673d7bf97..d8873604b213 100644
--- a/pkgs/applications/science/logic/verit/default.nix
+++ b/pkgs/applications/science/logic/verit/default.nix
@@ -15,6 +15,11 @@ stdenv.mkDerivation rec {
   # --disable-static actually enables static linking here...
   dontDisableStatic = true;
 
+  preConfigure = ''
+    CC=${stdenv.cc.targetPrefix}gcc
+    CXX=${stdenv.cc.targetPrefix}g++
+  '';
+
   makeFlags = [ "LEX=${flex}/bin/flex" ];
 
   preInstall = ''
diff --git a/pkgs/applications/virtualization/open-vm-tools/default.nix b/pkgs/applications/virtualization/open-vm-tools/default.nix
index e42c1d5dd1e4..13fa9d369b60 100644
--- a/pkgs/applications/virtualization/open-vm-tools/default.nix
+++ b/pkgs/applications/virtualization/open-vm-tools/default.nix
@@ -41,6 +41,11 @@ stdenv.mkDerivation rec {
      sed -i 's,/sbin/shutdown,shutdown,' lib/system/systemLinux.c
   '';
 
+  preConfigure = ''
+    CC=${stdenv.cc.targetPrefix}cc
+    CXX=${stdenv.cc.targetPrefix}c++
+  '';
+
   configureFlags = [ "--without-kernel-modules" "--without-xmlsecurity" ]
     ++ lib.optional (!withX) "--without-x";
 
diff --git a/pkgs/development/libraries/podofo/default.nix b/pkgs/development/libraries/podofo/default.nix
index 9a43470de3b7..51e2b5059749 100644
--- a/pkgs/development/libraries/podofo/default.nix
+++ b/pkgs/development/libraries/podofo/default.nix
@@ -19,6 +19,11 @@ stdenv.mkDerivation rec {
   # TODO(@Dridus) remove the ++ libc at next hash break
   buildInputs = [ lua5 ] ++ stdenv.lib.optional stdenv.isLinux stdenv.cc.libc;
 
+  preConfigure = ''
+    CC=${stdenv.cc.targetPrefix}cc
+    CXX=${stdenv.cc.targetPrefix}c++
+  '';
+
   cmakeFlags = "-DPODOFO_BUILD_SHARED=ON -DPODOFO_BUILD_STATIC=OFF";
 
   meta = {
diff --git a/pkgs/development/libraries/zeroc-ice/default.nix b/pkgs/development/libraries/zeroc-ice/default.nix
index 063d64c69058..4369a9765e58 100644
--- a/pkgs/development/libraries/zeroc-ice/default.nix
+++ b/pkgs/development/libraries/zeroc-ice/default.nix
@@ -27,6 +27,11 @@ stdenv.mkDerivation rec {
         --replace xcrun ""
   '';
 
+  preConfigure = ''
+    CC=${stdenv.cc.targetPrefix}cc
+    CXX=${stdenv.cc.targetPrefix}c++
+  '';
+
   makeFlags = [ "prefix=$(out)" "OPTIMIZE=yes" ];
 
   enableParallelBuilding = true;
diff --git a/pkgs/development/ocaml-modules/zarith/default.nix b/pkgs/development/ocaml-modules/zarith/default.nix
index e5d954970589..7b76919241de 100644
--- a/pkgs/development/ocaml-modules/zarith/default.nix
+++ b/pkgs/development/ocaml-modules/zarith/default.nix
@@ -28,7 +28,10 @@ stdenv.mkDerivation rec {
   propagatedBuildInputs = [ gmp ];
 
   patchPhase = "patchShebangs ./z_pp.pl";
+
   configurePhase = ''
+    CC=${stdenv.cc.targetPrefix}cc
+    CXX=${stdenv.cc.targetPrefix}c++
     ./configure -installdir $out/lib/ocaml/${ocaml.version}/site-lib
   '';
   preInstall = "mkdir -p $out/lib/ocaml/${ocaml.version}/site-lib";
diff --git a/pkgs/games/warmux/default.nix b/pkgs/games/warmux/default.nix
index a56afbbf44b5..29e8042ac7ac 100644
--- a/pkgs/games/warmux/default.nix
+++ b/pkgs/games/warmux/default.nix
@@ -19,6 +19,11 @@ stdenv.mkDerivation rec {
       gettext intltool libtool perl
     ];
 
+  preConfigure = ''
+    CC=${stdenv.cc.targetPrefix}cc
+    CXX=${stdenv.cc.targetPrefix}c++
+  '';
+
   configureFlagsArray = ("CFLAGS=-include ${zlib.dev}/include/zlib.h");
 
   patches = [ ./gcc-fix.patch ];
diff --git a/pkgs/games/warzone2100/default.nix b/pkgs/games/warzone2100/default.nix
index 6165cacfdca5..65e5669d86a6 100644
--- a/pkgs/games/warzone2100/default.nix
+++ b/pkgs/games/warzone2100/default.nix
@@ -30,6 +30,11 @@ stdenv.mkDerivation rec {
                       --replace "which %s" "${which}/bin/which %s"
   '';
 
+  preConfigure = ''
+    CC=${stdenv.cc.targetPrefix}cc
+    CXX=${stdenv.cc.targetPrefix}c++
+  '';
+
   configureFlags = [ "--with-distributor=NixOS" ];
 
   hardeningDisable = [ "format" ];