diff --git a/pkgs/development/interpreters/python/cpython/2.7/default.nix b/pkgs/development/interpreters/python/cpython/2.7/default.nix
index a934d6c3bcf2..98e5b4b1da0e 100644
--- a/pkgs/development/interpreters/python/cpython/2.7/default.nix
+++ b/pkgs/development/interpreters/python/cpython/2.7/default.nix
@@ -176,7 +176,8 @@ in stdenv.mkDerivation {
     LDFLAGS = stdenv.lib.optionalString (!stdenv.isDarwin) "-lgcc_s";
     inherit (mkPaths buildInputs) C_INCLUDE_PATH LIBRARY_PATH;
 
-    NIX_CFLAGS_COMPILE = optionalString stdenv.isDarwin "-msse2";
+    NIX_CFLAGS_COMPILE = optionalString stdenv.isDarwin "-msse2"
+      + optionalString hostPlatform.isMusl " -DTHREAD_STACK_SIZE=0x100000";
     DETERMINISTIC_BUILD = 1;
 
     setupHook = python-setup-hook sitePackages;
diff --git a/pkgs/development/interpreters/python/cpython/3.4/default.nix b/pkgs/development/interpreters/python/cpython/3.4/default.nix
index d4391d873af7..797a5be40ff3 100644
--- a/pkgs/development/interpreters/python/cpython/3.4/default.nix
+++ b/pkgs/development/interpreters/python/cpython/3.4/default.nix
@@ -105,6 +105,9 @@ in stdenv.mkDerivation {
     ${optionalString stdenv.isDarwin ''
        export NIX_CFLAGS_COMPILE="$NIX_CFLAGS_COMPILE -msse2"
        export MACOSX_DEPLOYMENT_TARGET=10.6
+     ''
+     + optionalString stdenv.hostPlatform.isMusl ''
+      export NIX_CFLAGS_COMPILE+=" -DTHREAD_STACK_SIZE=0x100000"
      ''}
   '';
 
diff --git a/pkgs/development/interpreters/python/cpython/3.5/default.nix b/pkgs/development/interpreters/python/cpython/3.5/default.nix
index 4f9e79c1d5f0..6dbf9a09cf56 100644
--- a/pkgs/development/interpreters/python/cpython/3.5/default.nix
+++ b/pkgs/development/interpreters/python/cpython/3.5/default.nix
@@ -99,6 +99,9 @@ in stdenv.mkDerivation {
     ${optionalString stdenv.isDarwin ''
        export NIX_CFLAGS_COMPILE="$NIX_CFLAGS_COMPILE -msse2"
        export MACOSX_DEPLOYMENT_TARGET=10.6
+     ''
+     + optionalString stdenv.hostPlatform.isMusl ''
+      export NIX_CFLAGS_COMPILE+=" -DTHREAD_STACK_SIZE=0x100000"
      ''}
   '';
 
diff --git a/pkgs/development/interpreters/python/cpython/3.6/default.nix b/pkgs/development/interpreters/python/cpython/3.6/default.nix
index 317a335b3448..63a70b7496db 100644
--- a/pkgs/development/interpreters/python/cpython/3.6/default.nix
+++ b/pkgs/development/interpreters/python/cpython/3.6/default.nix
@@ -122,6 +122,9 @@ in stdenv.mkDerivation {
     ${optionalString stdenv.isDarwin ''
        export NIX_CFLAGS_COMPILE="$NIX_CFLAGS_COMPILE -msse2"
        export MACOSX_DEPLOYMENT_TARGET=10.6
+     ''
+     + optionalString stdenv.hostPlatform.isMusl ''
+      export NIX_CFLAGS_COMPILE+=" -DTHREAD_STACK_SIZE=0x100000"
      ''}
   '';