diff --git a/pkgs/applications/misc/playonlinux/default.nix b/pkgs/applications/misc/playonlinux/default.nix
index fe9838fe0d97..e3b7c48d2b4b 100644
--- a/pkgs/applications/misc/playonlinux/default.nix
+++ b/pkgs/applications/misc/playonlinux/default.nix
@@ -9,7 +9,7 @@
 , imagemagick
 , netcat-gnu
 , p7zip
-, python2Packages
+, python2
 , unzip
 , wget
 , wine
@@ -27,25 +27,25 @@
 let
   version = "4.3.4";
 
-  binpath = stdenv.lib.makeBinPath
-    [ cabextract
-      python2Packages.python
-      gettext
-      glxinfo
-      gnupg
-      icoutils
-      imagemagick
-      netcat-gnu
-      p7zip
-      unzip
-      wget
-      wine
-      xdg-user-dirs
-      xterm
-      which
-      curl
-      jq
-    ];
+  binpath = stdenv.lib.makeBinPath [ 
+    cabextract
+    python
+    gettext
+    glxinfo
+    gnupg
+    icoutils
+    imagemagick
+    netcat-gnu
+    p7zip
+    unzip
+    wget
+    wine
+    xdg-user-dirs
+    xterm
+    which
+    curl
+    jq
+  ];
 
   ld32 =
     if stdenv.hostPlatform.system == "x86_64-linux" then "${stdenv.cc}/nix-support/dynamic-linker-m32"
@@ -54,6 +54,11 @@ let
   ld64 = "${stdenv.cc}/nix-support/dynamic-linker";
   libs = pkgs: stdenv.lib.makeLibraryPath [ xorg.libX11 libGL ];
 
+  python = python2.withPackages(ps: with ps; [
+    wxPython
+    setuptools
+  ]);
+
 in stdenv.mkDerivation {
   pname = "playonlinux";
   inherit version;
@@ -65,15 +70,13 @@ in stdenv.mkDerivation {
 
   nativeBuildInputs = [ makeWrapper ];
 
-  buildInputs =
-    [ python2Packages.python
-      python2Packages.wxPython
-      python2Packages.setuptools
-      xorg.libX11
-      libGL
-    ];
+  buildInputs = [ 
+    xorg.libX11
+    libGL
+    python
+  ];
 
-  patchPhase = ''
+  postPatch = ''
     patchShebangs python tests/python
     sed -i "s/ %F//g" etc/PlayOnLinux.desktop
   '';
@@ -85,7 +88,6 @@ in stdenv.mkDerivation {
     install -D -m644 etc/PlayOnLinux.desktop $out/share/applications/playonlinux.desktop
 
     makeWrapper $out/share/playonlinux/playonlinux $out/bin/playonlinux \
-      --prefix PYTHONPATH : $PYTHONPATH:$(toPythonPath "$out") \
       --prefix PATH : ${binpath}
 
     bunzip2 $out/share/playonlinux/bin/check_dd_x86.bz2