diff --git a/pkgs/applications/networking/newsreaders/liferea/default.nix b/pkgs/applications/networking/newsreaders/liferea/default.nix
index e38d5188dc2f..a5216b2902a6 100644
--- a/pkgs/applications/networking/newsreaders/liferea/default.nix
+++ b/pkgs/applications/networking/newsreaders/liferea/default.nix
@@ -33,7 +33,6 @@ stdenv.mkDerivation rec {
     for f in "$out"/bin/*; do
       wrapProgram "$f" \
         --prefix PYTHONPATH : "$(toPythonPath $out):$(toPythonPath ${pygobject3})" \
-        --prefix LD_LIBRARY_PATH : "${gnome3.libgnome_keyring}/lib" \
         --prefix GI_TYPELIB_PATH : "$GI_TYPELIB_PATH" \
         --prefix GIO_EXTRA_MODULES : "${gnome3.dconf}/lib/gio/modules:${glib_networking}/lib/gio/modules" \
         --prefix XDG_DATA_DIRS : "$XDG_ICON_DIRS:${gnome3.gnome_icon_theme}/share:${gnome3.gtk}/share:$out/share:$GSETTINGS_SCHEMAS_PATH"
diff --git a/pkgs/applications/virtualization/virt-manager/default.nix b/pkgs/applications/virtualization/virt-manager/default.nix
index 9df6967704af..08d53d83eedb 100644
--- a/pkgs/applications/virtualization/virt-manager/default.nix
+++ b/pkgs/applications/virtualization/virt-manager/default.nix
@@ -51,7 +51,6 @@ buildPythonPackage rec {
             --prefix GI_TYPELIB_PATH : $GI_TYPELIB_PATH \
             --prefix GIO_EXTRA_MODULES : "${dconf}/lib/gio/modules" \
             --prefix GSETTINGS_SCHEMA_DIR : $out/share/glib-2.0/schemas \
-            --prefix LD_LIBRARY_PATH : ${gtk3}/lib/:${libvirt-glib}/lib/:${vte}/lib:${gtkvnc}/lib${optionalString spiceSupport ":${spice_gtk}/lib"} \
             --prefix XDG_DATA_DIRS : "$out/share:${gsettings_desktop_schemas}/share:${gtk3}/share:$GSETTINGS_SCHEMAS_PATH:\$XDG_DATA_DIRS"
     done
 
diff --git a/pkgs/desktops/gnome-3/3.10/apps/gedit/default.nix b/pkgs/desktops/gnome-3/3.10/apps/gedit/default.nix
index 84a77e5a024a..6b9a69c738dc 100644
--- a/pkgs/desktops/gnome-3/3.10/apps/gedit/default.nix
+++ b/pkgs/desktops/gnome-3/3.10/apps/gedit/default.nix
@@ -25,7 +25,6 @@ stdenv.mkDerivation rec {
     wrapProgram "$out/bin/gedit" \
       --set GDK_PIXBUF_MODULE_FILE "$GDK_PIXBUF_MODULE_FILE" \
       --prefix GI_TYPELIB_PATH : "$GI_TYPELIB_PATH" \
-      --prefix LD_LIBRARY_PATH : "${gnome3.libpeas}/lib:${gnome3.gtksourceview}/lib" \
       --prefix XDG_DATA_DIRS : "${gnome3.gtksourceview}/share:${gnome3.gnome_themes_standard}/share:$XDG_ICON_DIRS:$GSETTINGS_SCHEMAS_PATH"
   '';
 
diff --git a/pkgs/desktops/gnome-3/3.10/apps/gnome-documents/default.nix b/pkgs/desktops/gnome-3/3.10/apps/gnome-documents/default.nix
index b393bb439316..a8c84d6a7698 100644
--- a/pkgs/desktops/gnome-3/3.10/apps/gnome-documents/default.nix
+++ b/pkgs/desktops/gnome-3/3.10/apps/gnome-documents/default.nix
@@ -28,17 +28,11 @@ stdenv.mkDerivation rec {
 
   enableParallelBuilding = true;
 
-  preFixup =
-    let
-      libPath = stdenv.lib.makeLibraryPath
-        [ evince gtk3 gnome3.tracker gnome3.gnome_online_accounts ];
-    in
-    ''
+  preFixup = ''
     substituteInPlace $out/bin/gnome-documents --replace gapplication "${glib}/bin/gapplication"
     wrapProgram "$out/bin/gnome-documents" \
       --set GDK_PIXBUF_MODULE_FILE "$GDK_PIXBUF_MODULE_FILE" \
       --prefix GI_TYPELIB_PATH : "$GI_TYPELIB_PATH" \
-      --prefix LD_LIBRARY_PATH ":" "${libPath}" \
       --prefix XDG_DATA_DIRS : "${gnome3.gnome_themes_standard}/share:$XDG_ICON_DIRS:$GSETTINGS_SCHEMAS_PATH" \
       --run "if [ -z \"\$XDG_CACHE_DIR\" ]; then XDG_CACHE_DIR=\$HOME/.cache; fi; if [ -w \"\$XDG_CACHE_DIR/..\" ]; then mkdir -p \"\$XDG_CACHE_DIR/gnome-documents\"; fi"
     rm $out/share/icons/hicolor/icon-theme.cache
diff --git a/pkgs/desktops/gnome-3/3.10/apps/gnome-music/default.nix b/pkgs/desktops/gnome-3/3.10/apps/gnome-music/default.nix
index b8d2bbc79efd..31d521e8c302 100644
--- a/pkgs/desktops/gnome-3/3.10/apps/gnome-music/default.nix
+++ b/pkgs/desktops/gnome-3/3.10/apps/gnome-music/default.nix
@@ -24,19 +24,11 @@ stdenv.mkDerivation rec {
 
   enableParallelBuilding = true;
 
-  preFixup =
-    let
-      libPath = stdenv.lib.makeLibraryPath
-        [ glib gtk3 libnotify tracker gnome3.grilo cairo
-          gst_all_1.gstreamer gst_all_1.gst-plugins-base
-          gst_all_1.gst-plugins-good gst_all_1.gst-plugins-bad ];
-    in
-    ''
+  preFixup = ''
     wrapProgram "$out/bin/gnome-music" \
       --set GDK_PIXBUF_MODULE_FILE "$GDK_PIXBUF_MODULE_FILE" \
       --prefix XDG_DATA_DIRS : "${gnome3.gnome_themes_standard}/share:$XDG_ICON_DIRS:$GSETTINGS_SCHEMAS_PATH" \
       --prefix GI_TYPELIB_PATH : "$GI_TYPELIB_PATH" \
-      --prefix LD_LIBRARY_PATH : "${libPath}" \
       --prefix GST_PLUGIN_SYSTEM_PATH_1_0 : "$GST_PLUGIN_SYSTEM_PATH_1_0" \
       --prefix GRL_PLUGIN_PATH : "${gnome3.grilo-plugins}/lib/grilo-0.2" \
       --prefix PYTHONPATH : "$PYTHONPATH"
diff --git a/pkgs/desktops/gnome-3/3.12/core/gnome-shell/default.nix b/pkgs/desktops/gnome-3/3.12/core/gnome-shell/default.nix
index dbb19f77d21e..6f6816efa5bd 100644
--- a/pkgs/desktops/gnome-3/3.12/core/gnome-shell/default.nix
+++ b/pkgs/desktops/gnome-3/3.12/core/gnome-shell/default.nix
@@ -35,7 +35,6 @@ stdenv.mkDerivation rec {
     wrapProgram "$out/bin/gnome-shell" \
       --prefix PATH : "${unzip}/bin" \
       --prefix GI_TYPELIB_PATH : "$GI_TYPELIB_PATH" \
-      --prefix LD_LIBRARY_PATH : "${accountsservice}/lib:${ibus}/lib:${gdm}/lib" \
       --set GDK_PIXBUF_MODULE_FILE "$GDK_PIXBUF_MODULE_FILE" \
       --prefix XDG_DATA_DIRS : "${gnome_themes_standard}/share:$out/share:$XDG_ICON_DIRS:$GSETTINGS_SCHEMAS_PATH"
 
diff --git a/pkgs/desktops/gnome-3/3.12/misc/gnome-tweak-tool/default.nix b/pkgs/desktops/gnome-3/3.12/misc/gnome-tweak-tool/default.nix
index 2eccb9a32cf9..1a48d6529a21 100644
--- a/pkgs/desktops/gnome-3/3.12/misc/gnome-tweak-tool/default.nix
+++ b/pkgs/desktops/gnome-3/3.12/misc/gnome-tweak-tool/default.nix
@@ -30,7 +30,6 @@ stdenv.mkDerivation rec {
       --set GDK_PIXBUF_MODULE_FILE "$GDK_PIXBUF_MODULE_FILE" \
       --prefix XDG_DATA_DIRS : "${gtk3}/share:${gnome3.gnome_themes_standard}/share:$out/share:$XDG_ICON_DIRS:$GSETTINGS_SCHEMAS_PATH" \
       --prefix GI_TYPELIB_PATH : "$GI_TYPELIB_PATH" \
-      --prefix LD_LIBRARY_PATH ":" "${libsoup}/lib:${gnome3.gnome_desktop}/lib:${libnotify}/lib:${gtk3}/lib:${atk}/lib" \
       --prefix PYTHONPATH : "$PYTHONPATH:$(toPythonPath $out)"
   '';
 
diff --git a/pkgs/desktops/gnome-3/3.12/misc/gpaste/default.nix b/pkgs/desktops/gnome-3/3.12/misc/gpaste/default.nix
index 56a5f18544f7..c303ccdf51e2 100644
--- a/pkgs/desktops/gnome-3/3.12/misc/gpaste/default.nix
+++ b/pkgs/desktops/gnome-3/3.12/misc/gpaste/default.nix
@@ -30,8 +30,7 @@ stdenv.mkDerivation rec {
       for i in $out/libexec/gpaste/*; do
         wrapProgram $i \
           --prefix XDG_DATA_DIRS : "$GSETTINGS_SCHEMAS_PATH" \
-          --prefix GI_TYPELIB_PATH : "$GI_TYPELIB_PATH" \
-          --prefix LD_LIBRARY_PATH : "${libPath}"
+          --prefix GI_TYPELIB_PATH : "$GI_TYPELIB_PATH"
       done
     '';
 
diff --git a/pkgs/development/libraries/gobject-introspection/absolute_shlib_path.patch b/pkgs/development/libraries/gobject-introspection/absolute_shlib_path.patch
new file mode 100644
index 000000000000..04bcc42a032f
--- /dev/null
+++ b/pkgs/development/libraries/gobject-introspection/absolute_shlib_path.patch
@@ -0,0 +1,25 @@
+--- ./giscanner/utils.py.orig	2014-08-14 22:05:05.055334080 +0200
++++ ./giscanner/utils.py	2014-08-14 22:05:24.687497334 +0200
+@@ -110,17 +110,11 @@
+     if dlname is None:
+         return None
+ 
+-    # Darwin uses absolute paths where possible; since the libtool files never
+-    # contain absolute paths, use the libdir field
+-    if platform.system() == 'Darwin':
+-        dlbasename = os.path.basename(dlname)
+-        libdir = _extract_libdir_field(la_file)
+-        if libdir is None:
+-            return dlbasename
+-        return libdir + '/' + dlbasename
+-    # From the comments in extract_libtool(), older libtools had
+-    # a path rather than the raw dlname
+-    return os.path.basename(dlname)
++    dlbasename = os.path.basename(dlname)
++    libdir = _extract_libdir_field(la_file)
++    if libdir is None:
++        return dlbasename
++    return libdir + '/' + dlbasename
+ 
+ 
+ def extract_libtool(la_file):
diff --git a/pkgs/development/libraries/gobject-introspection/default.nix b/pkgs/development/libraries/gobject-introspection/default.nix
index 7686fb308383..4b7ec1f41163 100644
--- a/pkgs/development/libraries/gobject-introspection/default.nix
+++ b/pkgs/development/libraries/gobject-introspection/default.nix
@@ -29,6 +29,8 @@ stdenv.mkDerivation rec {
 
   setupHook = ./setup-hook.sh;
 
+  patches = [ ./absolute_shlib_path.patch ];
+
   meta = with stdenv.lib; {
     description = "A middleware layer between C libraries and language bindings";
     homepage    = http://live.gnome.org/GObjectIntrospection;
diff --git a/pkgs/development/tools/misc/d-feet/default.nix b/pkgs/development/tools/misc/d-feet/default.nix
index 852c1b742195..df5fdbfab5a3 100644
--- a/pkgs/development/tools/misc/d-feet/default.nix
+++ b/pkgs/development/tools/misc/d-feet/default.nix
@@ -26,7 +26,6 @@ stdenv.mkDerivation rec {
       wrapProgram $out/bin/d-feet \
         --prefix PYTHONPATH : "$(toPythonPath $out):$(toPythonPath ${pygobject3})" \
         --prefix GI_TYPELIB_PATH : "$GI_TYPELIB_PATH" \
-        --prefix LD_LIBRARY_PATH : "${gtk3}/lib:${atk}/lib:${libwnck3}/lib" \
         --prefix XDG_DATA_DIRS : "$XDG_ICON_DIRS:$out/share"
 
       rm $out/share/icons/hicolor/icon-theme.cache