diff --git a/pkgs/development/libraries/qt-5/5.5/qtbase/default.nix b/pkgs/development/libraries/qt-5/5.5/qtbase/default.nix
index a8598f654dda..87fb3f08e2b9 100644
--- a/pkgs/development/libraries/qt-5/5.5/qtbase/default.nix
+++ b/pkgs/development/libraries/qt-5/5.5/qtbase/default.nix
@@ -269,6 +269,9 @@ stdenv.mkDerivation {
               done
           popd
       fi
+
+      # fixup .pc file (where to find 'moc' etc.)
+      sed "s|^host_bins=.*|host_bins=$dev/bin|" -i "$dev/lib/pkgconfig/Qt5Core.pc"
     '';
 
   inherit lndir;
diff --git a/pkgs/development/libraries/qt-5/5.6/qtbase/default.nix b/pkgs/development/libraries/qt-5/5.6/qtbase/default.nix
index 341ebe1198b7..b0e12ae99e48 100644
--- a/pkgs/development/libraries/qt-5/5.6/qtbase/default.nix
+++ b/pkgs/development/libraries/qt-5/5.6/qtbase/default.nix
@@ -267,6 +267,9 @@ stdenv.mkDerivation {
               done
           popd
       fi
+
+      # fixup .pc file (where to find 'moc' etc.)
+      sed "s|^host_bins=.*|host_bins=$dev/bin|" -i "$dev/lib/pkgconfig/Qt5Core.pc"
     '' + lib.optionalString stdenv.isDarwin ''
       fixDarwinDylibNames_rpath() {
         local flags=()
diff --git a/pkgs/development/libraries/qt-5/5.7/qtbase/default.nix b/pkgs/development/libraries/qt-5/5.7/qtbase/default.nix
index 934203950b09..7f0c71f64b25 100644
--- a/pkgs/development/libraries/qt-5/5.7/qtbase/default.nix
+++ b/pkgs/development/libraries/qt-5/5.7/qtbase/default.nix
@@ -228,6 +228,29 @@ stdenv.mkDerivation {
               done
           popd
       fi
+
+      # fixup .pc file (where to find 'moc' etc.)
+      sed "s|^host_bins=.*|host_bins=$dev/bin|" -i "$dev/lib/pkgconfig/Qt5Core.pc"
+    ''
+    # Don't move .prl files on darwin because they end up in
+    # "dev/lib/Foo.framework/Foo.prl" which interferes with subsequent
+    # use of lndir in the qtbase setup-hook. On Linux, the .prl files
+    # are in lib, and so do not cause a subsequent recreation of deep
+    # framework directory trees.
+    + lib.optionalString stdenv.isDarwin ''
+      fixDarwinDylibNames_rpath() {
+        local flags=()
+
+        for fn in "$@"; do
+          flags+=(-change "@rpath/$fn.framework/Versions/5/$fn" "$out/lib/$fn.framework/Versions/5/$fn")
+        done
+
+        for fn in "$@"; do
+          echo "$fn: fixing dylib"
+          install_name_tool -id "$out/lib/$fn.framework/Versions/5/$fn" "''${flags[@]}" "$out/lib/$fn.framework/Versions/5/$fn"
+        done
+      }
+      fixDarwinDylibNames_rpath "QtConcurrent" "QtPrintSupport" "QtCore" "QtSql" "QtDBus" "QtTest" "QtGui" "QtWidgets" "QtNetwork" "QtXml" "QtOpenGL"
     '';
 
   inherit lndir;
diff --git a/pkgs/development/libraries/qt-5/5.8/qtbase/default.nix b/pkgs/development/libraries/qt-5/5.8/qtbase/default.nix
index e4783ef9838a..cafaaecaa507 100644
--- a/pkgs/development/libraries/qt-5/5.8/qtbase/default.nix
+++ b/pkgs/development/libraries/qt-5/5.8/qtbase/default.nix
@@ -225,10 +225,35 @@ stdenv.mkDerivation {
               done
           popd
       fi
+
+      # fixup .pc file (where to find 'moc' etc.)
+      sed "s|^host_bins=.*|host_bins=$dev/bin|" -i "$dev/lib/pkgconfig/Qt5Core.pc"
+    ''
+    # Don't move .prl files on darwin because they end up in
+    # "dev/lib/Foo.framework/Foo.prl" which interferes with subsequent
+    # use of lndir in the qtbase setup-hook. On Linux, the .prl files
+    # are in lib, and so do not cause a subsequent recreation of deep
+    # framework directory trees.
+    + lib.optionalString stdenv.isDarwin ''
+      fixDarwinDylibNames_rpath() {
+        local flags=()
+
+        for fn in "$@"; do
+          flags+=(-change "@rpath/$fn.framework/Versions/5/$fn" "$out/lib/$fn.framework/Versions/5/$fn")
+        done
+
+        for fn in "$@"; do
+          echo "$fn: fixing dylib"
+          install_name_tool -id "$out/lib/$fn.framework/Versions/5/$fn" "''${flags[@]}" "$out/lib/$fn.framework/Versions/5/$fn"
+        done
+      }
+      fixDarwinDylibNames_rpath "QtConcurrent" "QtPrintSupport" "QtCore" "QtSql" "QtDBus" "QtTest" "QtGui" "QtWidgets" "QtNetwork" "QtXml" "QtOpenGL"
     '';
 
   inherit lndir;
-  setupHook = ../../qtbase-setup-hook.sh;
+  setupHook = if stdenv.isDarwin
+              then ../../qtbase-setup-hook-darwin.sh
+              else ../../qtbase-setup-hook.sh;
 
   enableParallelBuilding = true;