diff --git a/pkgs/development/libraries/glib/default.nix b/pkgs/development/libraries/glib/default.nix
index 37275489cc3d..024ccf2a4537 100644
--- a/pkgs/development/libraries/glib/default.nix
+++ b/pkgs/development/libraries/glib/default.nix
@@ -8,6 +8,7 @@
 , doCheck ? stdenv.config.doCheckByDefault or false
 , coreutils, dbus, libxml2, tzdata
 , desktop-file-utils, shared-mime-info
+, darwin
 }:
 
 with stdenv.lib;
@@ -44,6 +45,7 @@ let
     ln -sr -t "''${!outputInclude}/include/" "''${!outputInclude}"/lib/*/include/* 2>/dev/null || true
   '';
 
+  binPrograms = optional (!stdenv.isDarwin) "gapplication" ++ [ "gdbus" "gio" "gsettings" ];
   version = "2.58.2";
 in
 
@@ -83,7 +85,12 @@ stdenv.mkDerivation rec {
   ] ++ optionals stdenv.isLinux [
     libselinux
     utillinuxMinimal # for libmount
-  ];
+  ] ++ optionals stdenv.isDarwin (with darwin.apple_sdk.frameworks; [
+    AppKit Carbon Cocoa CoreFoundation CoreServices Foundation
+    # Needed for CFURLCreateFromFSRef, etc. which have deen deprecated
+    # since 10.9 and are not part of swift-corelibs CoreFoundation.
+    darwin.cf-private
+  ]);
 
   nativeBuildInputs = [
     meson ninja pkgconfig perl python3 gettext gtk-doc docbook_xsl docbook_xml_dtd_45 glibcLocales
@@ -121,15 +128,17 @@ stdenv.mkDerivation rec {
 
   postInstall = ''
     mkdir -p $bin/bin
-    for app in gapplication gdbus gio gsettings; do
+    for app in ${concatStringsSep " " binPrograms}; do
       mv "$dev/bin/$app" "$bin/bin"
     done
 
+  '' + optionalString (!stdenv.isDarwin) ''
     # Add gio-launch-desktop to $out so we can refer to it from $dev
     mkdir $out/bin
     mv "$dev/bin/gio-launch-desktop" "$out/bin/"
     ln -s "$out/bin/gio-launch-desktop" "$bin/bin/"
 
+  '' + ''
     moveToOutput "share/glib-2.0" "$dev"
     substituteInPlace "$dev/bin/gdbus-codegen" --replace "$out" "$dev"
     sed -i "$dev/bin/glib-gettextize" -e "s|^gettext_dir=.*|gettext_dir=$dev/share/glib-2.0/gettext|"
diff --git a/pkgs/development/tools/build-managers/meson/default.nix b/pkgs/development/tools/build-managers/meson/default.nix
index 17938ab47b37..96e044073259 100644
--- a/pkgs/development/tools/build-managers/meson/default.nix
+++ b/pkgs/development/tools/build-managers/meson/default.nix
@@ -44,6 +44,13 @@ python3Packages.buildPythonApplication rec {
       src = ./fix-rpath.patch;
       inherit (builtins) storeDir;
     })
+  ] ++ lib.optionals stdenv.isDarwin [
+    # We use custom Clang, which makes Meson think *not Apple*, while still
+    # relying on system linker. When it detects standard Clang, Meson will
+    # pass it `-Wl,-O1` flag but optimizations are not recognized by
+    # Mac linker.
+    # https://github.com/mesonbuild/meson/issues/4784
+    ./fix-objc-linking.patch
   ];
 
   setupHook = ./setup-hook.sh;
diff --git a/pkgs/development/tools/build-managers/meson/fix-objc-linking.patch b/pkgs/development/tools/build-managers/meson/fix-objc-linking.patch
new file mode 100644
index 000000000000..60a205828f5d
--- /dev/null
+++ b/pkgs/development/tools/build-managers/meson/fix-objc-linking.patch
@@ -0,0 +1,20 @@
+--- a/mesonbuild/environment.py
++++ b/mesonbuild/environment.py
+@@ -795,7 +795,7 @@
+                 compiler_type = self.get_gnu_compiler_type(defines)
+                 version = self.get_gnu_version_from_defines(defines)
+                 return GnuObjCCompiler(ccache + compiler, version, compiler_type, is_cross, exe_wrap, defines)
+-            if out.startswith('Apple LLVM'):
++            if out.startswith('Apple LLVM') or mesonlib.for_darwin(want_cross, self):
+                 return ClangObjCCompiler(ccache + compiler, version, CompilerType.CLANG_OSX, is_cross, exe_wrap)
+             if out.startswith('clang'):
+                 return ClangObjCCompiler(ccache + compiler, version, CompilerType.CLANG_STANDARD, is_cross, exe_wrap)
+@@ -822,7 +822,7 @@
+                 compiler_type = self.get_gnu_compiler_type(defines)
+                 version = self.get_gnu_version_from_defines(defines)
+                 return GnuObjCPPCompiler(ccache + compiler, version, compiler_type, is_cross, exe_wrap, defines)
+-            if out.startswith('Apple LLVM'):
++            if out.startswith('Apple LLVM') or mesonlib.for_darwin(want_cross, self):
+                 return ClangObjCPPCompiler(ccache + compiler, version, CompilerType.CLANG_OSX, is_cross, exe_wrap)
+             if out.startswith('clang'):
+                 return ClangObjCPPCompiler(ccache + compiler, version, CompilerType.CLANG_STANDARD, is_cross, exe_wrap)
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index e7edea7740d7..d65dfadb8263 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -419,7 +419,7 @@ in
   findXMLCatalogs = makeSetupHook { } ../build-support/setup-hooks/find-xml-catalogs.sh;
 
   wrapGAppsHook = makeSetupHook {
-    deps = [ gnome3.dconf.lib gnome3.gtk librsvg makeWrapper ];
+    deps = lib.optional (!stdenv.isDarwin) gnome3.dconf.lib ++ [ gtk3 librsvg makeWrapper ];
   } ../build-support/setup-hooks/wrap-gapps-hook.sh;
 
   separateDebugInfo = makeSetupHook { } ../build-support/setup-hooks/separate-debug-info.sh;