diff --git a/pkgs/development/ocaml-modules/bjack/default.nix b/pkgs/development/ocaml-modules/bjack/default.nix
index fa03194bde4a..a102d27c2879 100644
--- a/pkgs/development/ocaml-modules/bjack/default.nix
+++ b/pkgs/development/ocaml-modules/bjack/default.nix
@@ -1,4 +1,4 @@
-{ lib, buildDunePackage, fetchFromGitHub, dune-configurator, libsamplerate, libjack2 }:
+{ lib, stdenv, buildDunePackage, fetchFromGitHub, Accelerate, CoreAudio, dune-configurator, libsamplerate, libjack2 }:
 
 buildDunePackage rec {
   pname = "bjack";
@@ -13,7 +13,7 @@ buildDunePackage rec {
     sha256 = "1gf31a8i9byp6npn0x6gydcickn6sf5dnzmqr2c1b9jn2nl7334c";
   };
 
-  buildInputs = [ dune-configurator ];
+  buildInputs = [ dune-configurator ] ++ lib.optionals stdenv.isDarwin [ Accelerate CoreAudio ];
   propagatedBuildInputs = [ libsamplerate libjack2 ];
 
   meta = with lib; {
diff --git a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-av.nix b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-av.nix
index e8d71aa321e0..8c4d4e8c23c4 100644
--- a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-av.nix
+++ b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-av.nix
@@ -1,6 +1,10 @@
 { lib, buildDunePackage, dune-configurator, pkg-config, fetchFromGitHub, callPackage
+, AudioToolbox
 , ffmpeg-base ? callPackage ./base.nix { }
-, ffmpeg-avutil, ffmpeg-avcodec, ffmpeg }:
+, ffmpeg-avutil, ffmpeg-avcodec, ffmpeg
+, stdenv
+, VideoToolbox
+}:
 
 buildDunePackage {
   pname = "ffmpeg-av";
@@ -10,7 +14,7 @@ buildDunePackage {
   inherit (ffmpeg-base) version src useDune2;
 
   nativeBuildInputs = [ pkg-config ];
-  buildInputs = [ dune-configurator ];
+  buildInputs = [ dune-configurator ] ++ lib.optionals stdenv.isDarwin [ AudioToolbox VideoToolbox ];
   propagatedBuildInputs = [ ffmpeg-avutil ffmpeg-avcodec ffmpeg.dev ];
 
   doCheck = true;
diff --git a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avcodec.nix b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avcodec.nix
index 8ee5428c473e..442c80ab6a12 100644
--- a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avcodec.nix
+++ b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avcodec.nix
@@ -1,6 +1,9 @@
 { lib, buildDunePackage, dune-configurator, pkg-config, fetchFromGitHub, callPackage
+, AudioToolbox
 , ffmpeg-base ? callPackage ./base.nix { }
 , ffmpeg-avutil, ffmpeg
+, stdenv
+, VideoToolbox
 }:
 
 buildDunePackage {
@@ -11,7 +14,8 @@ buildDunePackage {
   inherit (ffmpeg-base) version src useDune2;
 
   nativeBuildInputs = [ pkg-config ];
-  buildInputs = [ dune-configurator ];
+  buildInputs = [ dune-configurator ]
+    ++ lib.optionals stdenv.isDarwin [ AudioToolbox VideoToolbox ];
   propagatedBuildInputs = [ ffmpeg-avutil ffmpeg.dev ];
 
   doCheck = true;
diff --git a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avdevice.nix b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avdevice.nix
index e6641a6ca030..72180afb9614 100644
--- a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avdevice.nix
+++ b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avdevice.nix
@@ -1,6 +1,14 @@
 { lib, buildDunePackage, dune-configurator, pkg-config, fetchFromGitHub, callPackage
+, AppKit
+, AudioToolbox
+, Cocoa
+, CoreImage
+, ForceFeedback
 , ffmpeg-base ? callPackage ./base.nix { }
 , ffmpeg-av, ffmpeg
+, OpenGL
+, stdenv
+, VideoToolbox
 }:
 
 buildDunePackage {
@@ -11,7 +19,8 @@ buildDunePackage {
   inherit (ffmpeg-base) version src useDune2;
 
   nativeBuildInputs = [ pkg-config ];
-  buildInputs = [ dune-configurator ];
+  buildInputs = [ dune-configurator ]
+    ++ lib.optionals stdenv.isDarwin [ AppKit AudioToolbox Cocoa CoreImage ForceFeedback OpenGL VideoToolbox ];
   propagatedBuildInputs = [ ffmpeg-av ffmpeg.dev ];
 
   doCheck = true;
diff --git a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avfilter.nix b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avfilter.nix
index 6479bbe55bf6..3b3b94988b17 100644
--- a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avfilter.nix
+++ b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avfilter.nix
@@ -1,6 +1,11 @@
 { lib, buildDunePackage, dune-configurator, pkg-config, fetchFromGitHub, callPackage
+, AppKit
+, CoreImage
 , ffmpeg-base ? callPackage ./base.nix { }
 , ffmpeg-avutil, ffmpeg
+, OpenGL
+, stdenv
+, VideoToolbox
 }:
 
 buildDunePackage {
@@ -11,7 +16,8 @@ buildDunePackage {
   inherit (ffmpeg-base) version src useDune2;
 
   nativeBuildInputs = [ pkg-config ];
-  buildInputs = [ dune-configurator ];
+  buildInputs = [ dune-configurator ]
+    ++ lib.optionals stdenv.isDarwin [ AppKit CoreImage OpenGL VideoToolbox ];
   propagatedBuildInputs = [ ffmpeg-avutil ffmpeg.dev ];
 
   doCheck = true;
diff --git a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avutil.nix b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avutil.nix
index 121fb115146e..7635fb6d1218 100644
--- a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avutil.nix
+++ b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-avutil.nix
@@ -1,4 +1,5 @@
-{ lib, buildDunePackage, dune-configurator, pkg-config, fetchFromGitHub, callPackage
+{ lib, stdenv, buildDunePackage, dune-configurator, pkg-config, fetchFromGitHub, callPackage
+, AudioToolbox, VideoToolbox
 , ffmpeg-base ? callPackage ./base.nix { }
 , ffmpeg
 }:
@@ -11,7 +12,7 @@ buildDunePackage {
   inherit (ffmpeg-base) version src useDune2;
 
   nativeBuildInputs = [ pkg-config ];
-  buildInputs = [ dune-configurator ];
+  buildInputs = [ dune-configurator ] ++ lib.optionals stdenv.isDarwin [ AudioToolbox VideoToolbox ];
   propagatedBuildInputs = [ ffmpeg.dev ];
 
   doCheck = true;
diff --git a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-swresample.nix b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-swresample.nix
index 92011e48eab6..801e00b6155f 100644
--- a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-swresample.nix
+++ b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-swresample.nix
@@ -1,6 +1,8 @@
 { lib, buildDunePackage, dune-configurator, pkg-config, fetchFromGitHub, callPackage
 , ffmpeg-base ? callPackage ./base.nix { }
 , ffmpeg-avutil, ffmpeg-avcodec, ffmpeg
+, stdenv
+, VideoToolbox
 }:
 
 buildDunePackage {
@@ -11,7 +13,7 @@ buildDunePackage {
   inherit (ffmpeg-base) version src useDune2;
 
   nativeBuildInputs = [ pkg-config ];
-  buildInputs = [ dune-configurator ];
+  buildInputs = [ dune-configurator ] ++ lib.optionals stdenv.isDarwin [ VideoToolbox ];
   propagatedBuildInputs = [ ffmpeg-avutil ffmpeg-avcodec ffmpeg.dev ];
 
   doCheck = true;
diff --git a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-swscale.nix b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-swscale.nix
index 9d97b722551b..f39ffbc96fa0 100644
--- a/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-swscale.nix
+++ b/pkgs/development/ocaml-modules/ffmpeg/ffmpeg-swscale.nix
@@ -1,6 +1,8 @@
 { lib, buildDunePackage, dune-configurator, pkg-config, fetchFromGitHub, callPackage
 , ffmpeg-base ? callPackage ./base.nix { }
 , ffmpeg-avutil, ffmpeg
+, stdenv
+, VideoToolbox
 }:
 
 buildDunePackage {
@@ -11,7 +13,7 @@ buildDunePackage {
   inherit (ffmpeg-base) version src useDune2;
 
   nativeBuildInputs = [ pkg-config ];
-  buildInputs = [ dune-configurator ];
+  buildInputs = [ dune-configurator ] ++ lib.optionals stdenv.isDarwin [ VideoToolbox ];
   propagatedBuildInputs = [ ffmpeg-avutil ffmpeg.dev ];
 
   doCheck = true;
diff --git a/pkgs/development/ocaml-modules/gstreamer/default.nix b/pkgs/development/ocaml-modules/gstreamer/default.nix
index 4ef3e98cb75e..34407299914a 100644
--- a/pkgs/development/ocaml-modules/gstreamer/default.nix
+++ b/pkgs/development/ocaml-modules/gstreamer/default.nix
@@ -1,4 +1,4 @@
-{ lib, buildDunePackage, fetchFromGitHub, dune-configurator, pkg-config, glib, gst_all_1 }:
+{ lib, stdenv, buildDunePackage, fetchFromGitHub, dune-configurator, AppKit, Foundation, pkg-config, glib, gst_all_1 }:
 
 buildDunePackage rec {
   pname = "gstreamer";
@@ -12,7 +12,7 @@ buildDunePackage rec {
   };
 
   nativeBuildInputs = [ pkg-config ];
-  buildInputs = [ dune-configurator ];
+  buildInputs = [ dune-configurator ] ++ lib.optionals stdenv.isDarwin [ AppKit Foundation ];
   propagatedBuildInputs = [ glib.dev gst_all_1.gstreamer.dev gst_all_1.gst-plugins-base ];
 
   CFLAGS_COMPILE = [
diff --git a/pkgs/development/ocaml-modules/labltk/default.nix b/pkgs/development/ocaml-modules/labltk/default.nix
index fd7e59424547..4d5c4ae303e8 100644
--- a/pkgs/development/ocaml-modules/labltk/default.nix
+++ b/pkgs/development/ocaml-modules/labltk/default.nix
@@ -1,4 +1,4 @@
-{ stdenv, lib, makeWrapper, fetchzip, ocaml, findlib, tcl, tk }:
+{ stdenv, lib, makeWrapper, fetchzip, Cocoa, ocaml, findlib, tcl, tk }:
 
 let
  params =
@@ -60,7 +60,7 @@ stdenv.mkDerivation rec {
   pname = "ocaml${ocaml.version}-labltk";
 
   nativeBuildInputs = [ ocaml findlib makeWrapper ];
-  buildInputs = [ tcl tk ];
+  buildInputs = [ tcl tk ] ++ lib.optionals stdenv.isDarwin [ Cocoa ];
 
   configureFlags = [ "--use-findlib" "--installbindir" "$(out)/bin" ];
   dontAddPrefix = true;
diff --git a/pkgs/development/ocaml-modules/ocaml-libvirt/default.nix b/pkgs/development/ocaml-modules/ocaml-libvirt/default.nix
index c321ca2bcb47..67741516af19 100644
--- a/pkgs/development/ocaml-modules/ocaml-libvirt/default.nix
+++ b/pkgs/development/ocaml-modules/ocaml-libvirt/default.nix
@@ -1,4 +1,4 @@
-{ lib, stdenv, fetchFromGitLab, libvirt, autoreconfHook, pkg-config, ocaml, findlib, perl }:
+{ lib, stdenv, fetchFromGitLab, libvirt, AppKit, Foundation, autoreconfHook, pkg-config, ocaml, findlib, perl }:
 
 lib.throwIfNot (lib.versionAtLeast ocaml.version "4.02")
   "libvirt is not available for OCaml ${ocaml.version}"
@@ -18,6 +18,11 @@ stdenv.mkDerivation rec {
 
   nativeBuildInputs = [ autoreconfHook pkg-config findlib perl ocaml ];
 
+  buildInputs = lib.optionals stdenv.isDarwin [
+    Foundation
+    AppKit
+  ];
+
   strictDeps = true;
 
   buildFlags = [ "all" "opt" "CPPFLAGS=-Wno-error" ];
diff --git a/pkgs/top-level/ocaml-packages.nix b/pkgs/top-level/ocaml-packages.nix
index ee3b3ad21a1a..f037f5b7cc9d 100644
--- a/pkgs/top-level/ocaml-packages.nix
+++ b/pkgs/top-level/ocaml-packages.nix
@@ -86,7 +86,9 @@ let
 
     bitv = callPackage ../development/ocaml-modules/bitv { };
 
-    bjack = callPackage ../development/ocaml-modules/bjack { };
+    bjack = callPackage ../development/ocaml-modules/bjack {
+      inherit (pkgs.darwin.apple_sdk.frameworks) Accelerate CoreAudio;
+    };
 
     bls12-381 = callPackage ../development/ocaml-modules/bls12-381 { };
     bls12-381-gen = callPackage ../development/ocaml-modules/bls12-381/gen.nix { };
@@ -450,24 +452,31 @@ let
     ffmpeg = callPackage ../development/ocaml-modules/ffmpeg { };
     ffmpeg-avutil = callPackage ../development/ocaml-modules/ffmpeg/ffmpeg-avutil.nix {
       inherit (pkgs) ffmpeg;
+      inherit (pkgs.darwin.apple_sdk.frameworks) AudioToolbox VideoToolbox;
     };
     ffmpeg-avcodec = callPackage ../development/ocaml-modules/ffmpeg/ffmpeg-avcodec.nix {
       inherit (pkgs) ffmpeg;
+      inherit (pkgs.darwin.apple_sdk.frameworks) AudioToolbox VideoToolbox;
     };
     ffmpeg-avfilter = callPackage ../development/ocaml-modules/ffmpeg/ffmpeg-avfilter.nix {
       inherit (pkgs) ffmpeg;
+      inherit (pkgs.darwin.apple_sdk.frameworks) AppKit CoreImage OpenGL VideoToolbox;
     };
     ffmpeg-swscale = callPackage ../development/ocaml-modules/ffmpeg/ffmpeg-swscale.nix {
       inherit (pkgs) ffmpeg;
+      inherit (pkgs.darwin.apple_sdk.frameworks) VideoToolbox;
     };
     ffmpeg-swresample = callPackage ../development/ocaml-modules/ffmpeg/ffmpeg-swresample.nix {
       inherit (pkgs) ffmpeg;
+      inherit (pkgs.darwin.apple_sdk.frameworks) VideoToolbox;
     };
     ffmpeg-av = callPackage ../development/ocaml-modules/ffmpeg/ffmpeg-av.nix {
       inherit (pkgs) ffmpeg;
+      inherit (pkgs.darwin.apple_sdk.frameworks) AudioToolbox VideoToolbox;
     };
     ffmpeg-avdevice = callPackage ../development/ocaml-modules/ffmpeg/ffmpeg-avdevice.nix {
       inherit (pkgs) ffmpeg;
+      inherit (pkgs.darwin.apple_sdk.frameworks) AppKit AudioToolbox Cocoa CoreImage ForceFeedback OpenGL VideoToolbox;
     };
 
     fiber = callPackage ../development/ocaml-modules/fiber { };
@@ -524,7 +533,9 @@ let
       inherit (pkgs) gsl;
     };
 
-    gstreamer = callPackage ../development/ocaml-modules/gstreamer { };
+    gstreamer = callPackage ../development/ocaml-modules/gstreamer {
+      inherit (pkgs.darwin.apple_sdk.frameworks) AppKit Foundation;
+    };
 
     h2 = callPackage ../development/ocaml-modules/h2 { };
 
@@ -707,7 +718,9 @@ let
       then callPackage ../development/ocaml-modules/lablgtk-extras { }
       else callPackage ../development/ocaml-modules/lablgtk-extras/1.4.nix { };
 
-    labltk = callPackage ../development/ocaml-modules/labltk { };
+    labltk = callPackage ../development/ocaml-modules/labltk {
+      inherit (pkgs.darwin.apple_sdk.frameworks) Cocoa;
+    };
 
     lacaml = callPackage ../development/ocaml-modules/lacaml { };
 
@@ -1000,7 +1013,9 @@ let
     ocamlgraph = callPackage ../development/ocaml-modules/ocamlgraph { };
     ocamlgraph_gtk = callPackage ../development/ocaml-modules/ocamlgraph/gtk.nix { };
 
-    ocaml_libvirt = callPackage ../development/ocaml-modules/ocaml-libvirt { };
+    ocaml_libvirt = callPackage ../development/ocaml-modules/ocaml-libvirt {
+      inherit (pkgs.darwin.apple_sdk.frameworks) Foundation AppKit;
+    };
 
     ocamlify = callPackage ../development/tools/ocaml/ocamlify { };