diff --git a/pkgs/development/python-modules/weasyprint/default.nix b/pkgs/development/python-modules/weasyprint/default.nix
index ecc13b1d6377..a3c8181cf7de 100644
--- a/pkgs/development/python-modules/weasyprint/default.nix
+++ b/pkgs/development/python-modules/weasyprint/default.nix
@@ -1,17 +1,24 @@
 { buildPythonPackage,
   fetchPypi,
   fetchpatch,
+  pytestCheckHook,
+  brotli,
   cairosvg,
+  fonttools,
+  pydyf,
   pyphen,
   cffi,
   cssselect,
   lxml,
   html5lib,
   tinycss,
+  zopfli,
   glib,
+  harfbuzz,
   pango,
   fontconfig,
   lib, stdenv,
+  ghostscript,
   pytest,
   pytest-runner,
   pytest-isort,
@@ -23,35 +30,48 @@
 
 buildPythonPackage rec {
   pname = "weasyprint";
-  version = "52";
+  version = "53.4";
   disabled = !isPy3k;
 
-  # excluded test needs the Ahem font
-  checkPhase = ''
-    runHook preCheck
-    pytest -k 'not test_font_stretch'
-    runHook postCheck
-  '';
+  pytestFlagsArray = [
+    # setup.py is auto-generated and doesn't pass the flake8 check
+    "--ignore=setup.py"
+    # ffi.py is patched by us and doesn't pass the flake8 check
+    "--ignore=weasyprint/text/ffi.py"
+  ];
 
-  # ignore failing flake8-test
-  prePatch = ''
-    substituteInPlace setup.cfg \
-        --replace '[tool:pytest]' '[tool:pytest]\nflake8-ignore = E501'
-  '';
+  disabledTests = [
+    # test_font_stretch needs the Ahem font (fails on macOS)
+    "test_font_stretch"
+  ];
 
-  checkInputs = [ pytest pytest-runner pytest-isort pytest-flake8 pytest-cov ];
+  checkInputs = [
+    pytestCheckHook
+    ghostscript
+    pytest
+    pytest-runner
+    pytest-isort
+    pytest-flake8
+    pytest-cov
+  ];
 
   FONTCONFIG_FILE = "${fontconfig.out}/etc/fonts/fonts.conf";
 
-  propagatedBuildInputs = [ cairosvg pyphen cffi cssselect lxml html5lib tinycss ];
+  propagatedBuildInputs = [
+    brotli
+    cairosvg
+    cffi
+    cssselect
+    fonttools
+    html5lib
+    lxml
+    pydyf
+    pyphen
+    tinycss
+    zopfli
+  ];
 
-  # 47043a1fd7e50a892b9836466f521df85d597c4.patch can be removed after next release of weasyprint, see:
-  # https://github.com/Kozea/WeasyPrint/issues/1333#issuecomment-818062970
   patches = [
-    (fetchpatch {
-      url = "https://github.com/Kozea/WeasyPrint/commit/47043a1fd7e50a892b9836466f521df85d597c44.patch";
-      sha256 = "0l9z0hrav3bcdajlg3vbzljq0lkw7hlj8ppzrq3v21hbj1il1nsb";
-    })
     (substituteAll {
       src = ./library-paths.patch;
       fontconfig = "${fontconfig.lib}/lib/libfontconfig${stdenv.hostPlatform.extensions.sharedLibrary}";
@@ -59,13 +79,14 @@ buildPythonPackage rec {
       gobject = "${glib.out}/lib/libgobject-2.0${stdenv.hostPlatform.extensions.sharedLibrary}";
       pango = "${pango.out}/lib/libpango-1.0${stdenv.hostPlatform.extensions.sharedLibrary}";
       pangocairo = "${pango.out}/lib/libpangocairo-1.0${stdenv.hostPlatform.extensions.sharedLibrary}";
+      harfbuzz = "${harfbuzz.out}/lib/libharfbuzz${stdenv.hostPlatform.extensions.sharedLibrary}";
     })
   ];
 
   src = fetchPypi {
     inherit version;
-    pname = "WeasyPrint";
-    sha256 = "0rwf43111ws74m8b1alkkxzz57g0np3vmd8as74adwnxslfcg4gs";
+    pname = "weasyprint";
+    sha256 = "sha256-EMyxfVXHMJa98e3T7+WMuFWwfkwwfZutTryaPxP/RYA=";
   };
 
   meta = with lib; {
diff --git a/pkgs/development/python-modules/weasyprint/library-paths.patch b/pkgs/development/python-modules/weasyprint/library-paths.patch
index c6eb87c94585..9a10990fd43f 100644
--- a/pkgs/development/python-modules/weasyprint/library-paths.patch
+++ b/pkgs/development/python-modules/weasyprint/library-paths.patch
@@ -1,38 +1,31 @@
-diff --git a/weasyprint/fonts.py b/weasyprint/fonts.py
-index 79e3b5b..4438eb4 100644
---- a/weasyprint/fonts.py
-+++ b/weasyprint/fonts.py
-@@ -45,11 +45,8 @@ else:
-     # with OSError: dlopen() failed to load a library: cairo / cairo-2
-     # So let's hope we find the same file as cairo already did ;)
-     # Same applies to pangocairo requiring pangoft2
--    fontconfig = dlopen(ffi, 'fontconfig', 'libfontconfig',
--                        'libfontconfig-1.dll',
--                        'libfontconfig.so.1', 'libfontconfig-1.dylib')
--    pangoft2 = dlopen(ffi, 'pangoft2-1.0', 'libpangoft2-1.0-0',
--                      'libpangoft2-1.0.so.0', 'libpangoft2-1.0.dylib')
-+    fontconfig = dlopen(ffi, '@fontconfig@')
-+    pangoft2 = dlopen(ffi, '@pangoft2@')
- 
-     ffi.cdef('''
-         // FontConfig
-diff --git a/weasyprint/text.py b/weasyprint/text.py
-index 1dc5e4d..b070bad 100644
---- a/weasyprint/text.py
-+++ b/weasyprint/text.py
-@@ -255,12 +255,9 @@ def dlopen(ffi, *names):
+diff --git a/weasyprint/text/ffi.py b/weasyprint/text/ffi.py
+index 0734cbea..22e31a5e 100644
+--- a/weasyprint/text/ffi.py
++++ b/weasyprint/text/ffi.py
+@@ -387,21 +387,11 @@ def _dlopen(ffi, *names):
      return ffi.dlopen(names[0])  # pragma: no cover
  
  
--gobject = dlopen(ffi, 'gobject-2.0', 'libgobject-2.0-0', 'libgobject-2.0.so.0',
--                 'libgobject-2.0.dylib')
--pango = dlopen(ffi, 'pango-1.0', 'libpango-1.0-0', 'libpango-1.0.so.0',
--               'libpango-1.0.dylib')
--pangocairo = dlopen(ffi, 'pangocairo-1.0', 'libpangocairo-1.0-0',
--                    'libpangocairo-1.0.so.0', 'libpangocairo-1.0.dylib')
-+gobject = dlopen(ffi, '@gobject@')
-+pango = dlopen(ffi, '@pango@')
-+pangocairo = dlopen(ffi, '@pangocairo@')
+-gobject = _dlopen(
+-    ffi, 'gobject-2.0-0', 'gobject-2.0', 'libgobject-2.0-0',
+-    'libgobject-2.0.so.0', 'libgobject-2.0.dylib')
+-pango = _dlopen(
+-    ffi, 'pango-1.0-0', 'pango-1.0', 'libpango-1.0-0', 'libpango-1.0.so.0',
+-    'libpango-1.0.dylib')
+-harfbuzz = _dlopen(
+-    ffi, 'harfbuzz', 'harfbuzz-0.0', 'libharfbuzz-0',
+-    'libharfbuzz.so.0', 'libharfbuzz.so.0', 'libharfbuzz.0.dylib')
+-fontconfig = _dlopen(
+-    ffi, 'fontconfig-1', 'fontconfig', 'libfontconfig', 'libfontconfig-1.dll',
+-    'libfontconfig.so.1', 'libfontconfig-1.dylib')
+-pangoft2 = _dlopen(
+-    ffi, 'pangoft2-1.0-0', 'pangoft2-1.0', 'libpangoft2-1.0-0',
+-    'libpangoft2-1.0.so.0', 'libpangoft2-1.0.dylib')
++gobject = _dlopen(ffi, '@gobject@')
++pango = _dlopen(ffi, '@pango@')
++harfbuzz = _dlopen(ffi, '@harfbuzz@')
++fontconfig = _dlopen(ffi, '@fontconfig@')
++pangoft2 = _dlopen(ffi, '@pangoft2@')
  
  gobject.g_type_init()
- 
+