diff --git a/pkgs/development/libraries/opensubdiv/default.nix b/pkgs/development/libraries/opensubdiv/default.nix
index b253a27a7db3..f5f84ee15463 100644
--- a/pkgs/development/libraries/opensubdiv/default.nix
+++ b/pkgs/development/libraries/opensubdiv/default.nix
@@ -39,7 +39,16 @@ stdenv.mkDerivation {
 
   enableParallelBuilding = true;
 
-  postInstall = "rm $out/lib/*.a";
+  postInstall =
+    ''
+      rm $out/lib/*.a
+    '' + lib.optionalString cudaSupport ''
+      # Drop cudatoolkit reference from the closure. We'll get
+      # libOpenCL from /run/opengl-driver.
+      s=${cudatoolkit}/lib
+      t=$(for ((i = 0; i < ''${#s}; i++)); do echo -n X; done)
+      sed -i $out/lib/libosdGPU.so.* -e "s|$s|$t|g"
+    '';
 
   meta = {
     description = "An Open-Source subdivision surface library";