diff --git a/pkgs/applications/science/math/calc/default.nix b/pkgs/applications/science/math/calc/default.nix
index 19f769e4365c..b8ed7ffac3cd 100644
--- a/pkgs/applications/science/math/calc/default.nix
+++ b/pkgs/applications/science/math/calc/default.nix
@@ -34,6 +34,9 @@ stdenv.mkDerivation rec {
     wrapProgram $out/bin/calc --prefix LD_LIBRARY_PATH : $out/lib
   '';
 
+  # Hack to avoid TMPDIR in RPATHs.
+  preFixup = ''rm -rf "$(pwd)" '';
+
   meta = {
     description = "C-style arbitrary precision calculator";
     homepage = http://www.isthe.com/chongo/tech/comp/calc/;
diff --git a/pkgs/development/compilers/bigloo/default.nix b/pkgs/development/compilers/bigloo/default.nix
index 3599ff750c26..bf2272a75c17 100644
--- a/pkgs/development/compilers/bigloo/default.nix
+++ b/pkgs/development/compilers/bigloo/default.nix
@@ -32,6 +32,9 @@ stdenv.mkDerivation rec {
 
   checkTarget = "test";
 
+  # Hack to avoid TMPDIR in RPATHs.
+  preFixup = ''rm -rf "$(pwd)" '';
+
   meta = {
     description = "Efficient Scheme compiler";
     homepage    = http://www-sop.inria.fr/indes/fp/Bigloo/;
diff --git a/pkgs/development/compilers/swift/default.nix b/pkgs/development/compilers/swift/default.nix
index 4b918c9e32a9..839ecdbeb652 100644
--- a/pkgs/development/compilers/swift/default.nix
+++ b/pkgs/development/compilers/swift/default.nix
@@ -253,6 +253,9 @@ stdenv.mkDerivation rec {
     ln -s ${binutils}/bin/ar $out/bin/ar
   '';
 
+  # Hack to avoid TMPDIR in RPATHs.
+  preFixup = ''rm -rf "$(pwd)" '';
+
   meta = with stdenv.lib; {
     description = "The Swift Programming Language";
     homepage = "https://github.com/apple/swift";
diff --git a/pkgs/development/libraries/libftdi/default.nix b/pkgs/development/libraries/libftdi/default.nix
index 36f4a04c9df6..f0d05c0b263f 100644
--- a/pkgs/development/libraries/libftdi/default.nix
+++ b/pkgs/development/libraries/libftdi/default.nix
@@ -12,6 +12,9 @@ stdenv.mkDerivation rec {
 
   propagatedBuildInputs = [ libusb ];
 
+  # Hack to avoid TMPDIR in RPATHs.
+  preFixup = ''rm -rf "$(pwd)" '';
+
   meta = {
     description = "A library to talk to FTDI chips using libusb";
     homepage = http://www.intra2net.com/en/developer/libftdi/;
diff --git a/pkgs/games/klavaro/default.nix b/pkgs/games/klavaro/default.nix
index 2ca105af19d2..162543da10c4 100644
--- a/pkgs/games/klavaro/default.nix
+++ b/pkgs/games/klavaro/default.nix
@@ -16,6 +16,9 @@ stdenv.mkDerivation rec {
       --prefix LD_LIBRARY_PATH : $out/lib
   '';
 
+  # Hack to avoid TMPDIR in RPATHs.
+  preFixup = ''rm -rf "$(pwd)" '';
+
   meta = {
     description = "Just another free touch typing tutor program";
     homepage = http://klavaro.sourceforge.net/;
diff --git a/pkgs/os-specific/linux/libsmbios/default.nix b/pkgs/os-specific/linux/libsmbios/default.nix
index e2b675fb4ffa..eaf6d98ba9d8 100644
--- a/pkgs/os-specific/linux/libsmbios/default.nix
+++ b/pkgs/os-specific/linux/libsmbios/default.nix
@@ -23,6 +23,9 @@ stdenv.mkDerivation {
       cp -va "out/public-include/"* "$out/include/"
     '';
 
+  # Hack to avoid TMPDIR in RPATHs.
+  preFixup = ''rm -rf "$(pwd)" '';
+
   meta = {
     homepage = "http://linux.dell.com/libsmbios/main";
     description = "A library to obtain BIOS information";
diff --git a/pkgs/tools/security/ssdeep/default.nix b/pkgs/tools/security/ssdeep/default.nix
index b581d8007947..0a9804a743bc 100644
--- a/pkgs/tools/security/ssdeep/default.nix
+++ b/pkgs/tools/security/ssdeep/default.nix
@@ -9,6 +9,9 @@ stdenv.mkDerivation rec {
     sha256 = "1igqy0j7jrklb8fdlrm6ald4cyl1fda5ipfl8crzyl6bax2ajk3f";
   };
 
+  # Hack to avoid TMPDIR in RPATHs.
+  preFixup = ''rm -rf "$(pwd)" '';
+
   # For some reason (probably a build system bug), the binary isn't
   # properly linked to $out/lib to find libfuzzy.so
   postFixup = stdenv.lib.optionalString (!stdenv.isDarwin) ''