diff --git a/pkgs/applications/science/biology/EZminc/default.nix b/pkgs/applications/science/biology/EZminc/default.nix
index a2ba038c0599..6c140b03ee4b 100644
--- a/pkgs/applications/science/biology/EZminc/default.nix
+++ b/pkgs/applications/science/biology/EZminc/default.nix
@@ -25,5 +25,6 @@ stdenv.mkDerivation rec {
     maintainers = with maintainers; [ bcdarwin ];
     platforms = platforms.unix;
     license = licenses.free;
+    broken = true;  # ITK5 compatibility issue (https://github.com/BIC-MNI/EZminc/issues/15)
   };
 }