diff --git a/pkgs/applications/office/pyspread/default.nix b/pkgs/applications/office/pyspread/default.nix
new file mode 100644
index 000000000000..5b7a80747d09
--- /dev/null
+++ b/pkgs/applications/office/pyspread/default.nix
@@ -0,0 +1,68 @@
+{ lib
+, buildPythonApplication
+, fetchPypi
+, makePythonPath
+, dateutil
+, matplotlib
+, numpy
+, pyenchant
+, pyqt5
+, pytest
+, python
+, qtsvg
+, runtimeShell
+, wrapQtAppsHook
+}:
+
+buildPythonApplication rec {
+  pname = "pyspread";
+  version = "1.99.5";
+
+  src = fetchPypi {
+    inherit pname version;
+    sha256 = "sha256-05bC+Uvx72FAh3qxkgXm8jdb/gHRv1D/M7tjOEdE3Xg=";
+  };
+
+  pythonLibs = [
+    dateutil
+    matplotlib
+    numpy
+    pyenchant
+    pyqt5
+  ];
+
+  nativeBuildInputs = [ wrapQtAppsHook ];
+  buildInputs = pythonLibs ++ [
+    qtsvg
+  ];
+
+  doCheck = false; # it fails miserably with a core dump
+
+  fixupPhase = ''
+    runHook preFixup
+    sed -i -e "s|#!/bin/bash|#!${runtimeShell}|" $out/bin/pyspread
+    wrapProgram $out/bin/pyspread \
+      --prefix PYTHONPATH ':' $(toPythonPath $out):${makePythonPath pythonLibs} \
+      --prefix PATH ':' ${python}/bin/ \
+      ''${qtWrapperArgs[@]}
+    runHook postFixup
+  '';
+
+  meta = with lib; {
+    homepage = "https://pyspread.gitlab.io/";
+    description = "A Python-oriented spreadsheet application";
+    longDescription = ''
+      pyspread is a non-traditional spreadsheet application that is based on and
+      written in the programming language Python. The goal of pyspread is to be
+      the most pythonic spreadsheet.
+
+      pyspread expects Python expressions in its grid cells, which makes a
+      spreadsheet specific language obsolete. Each cell returns a Python object
+      that can be accessed from other cells. These objects can represent
+      anything including lists or matrices.
+    '';
+    license = with licenses; gpl3Plus;
+    maintainers = with maintainers; [ AndersonTorres ];
+    platforms = with platforms; all;
+  };
+}
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index b892150a23c1..9c012242c38a 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -7184,6 +7184,10 @@ in
 
   pympress = callPackage ../applications/office/pympress { };
 
+  pyspread = python3Packages.callPackage ../applications/office/pyspread {
+    inherit (qt5) qtsvg wrapQtAppsHook;
+  };
+
   pythonIRClib = pythonPackages.pythonIRClib;
 
   pyditz = callPackage ../applications/misc/pyditz {