diff --git a/pkgs/applications/video/natron/config.pri b/pkgs/applications/video/natron/config.pri
deleted file mode 100644
index c0d236c6b975..000000000000
--- a/pkgs/applications/video/natron/config.pri
+++ /dev/null
@@ -1,20 +0,0 @@
-boost: LIBS += -lboost_serialization
-expat: LIBS += -lexpat
-expat: PKGCONFIG -= expat
-cairo {
-        PKGCONFIG += cairo
-        LIBS -=  $$system(pkg-config --variable=libdir cairo)/libcairo.a
-}
-pyside {
-        PKGCONFIG -= pyside
-        INCLUDEPATH += $$system(pkg-config --variable=includedir pyside)
-        INCLUDEPATH += $$system(pkg-config --variable=includedir pyside)/QtCore
-        INCLUDEPATH += $$system(pkg-config --variable=includedir pyside)/QtGui
-        INCLUDEPATH += $$system(pkg-config --variable=includedir QtGui)
-        LIBS += -lpyside-python2.7
-}
-shiboken {
-        PKGCONFIG -= shiboken
-        INCLUDEPATH += $$system(pkg-config --variable=includedir shiboken)
-        LIBS += -lshiboken-python2.7
-}
diff --git a/pkgs/applications/video/natron/default.nix b/pkgs/applications/video/natron/default.nix
index b41503b73597..d5c603998f3d 100644
--- a/pkgs/applications/video/natron/default.nix
+++ b/pkgs/applications/video/natron/default.nix
@@ -1,96 +1,29 @@
-{ lib, stdenv, fetchurl, qt4, pkg-config, boost, expat, cairo, python2Packages,
-  cmake, flex, bison, pango, librsvg, librevenge, libxml2, libcdr, libzip,
-  poppler, imagemagick, openexr, ffmpeg, opencolorio_1, openimageio_1,
-  qmake4Hook, libpng, libGL, lndir, libraw, openjpeg, libwebp, fetchFromGitHub }:
+{ lib
+, stdenv
+, fetchFromGitHub
+, cmake
+, pkg-config
+, wrapQtAppsHook
+, boost
+, cairo
+, ceres-solver
+, expat
+, extra-cmake-modules
+, glog
+, libXdmcp
+, python3
+, wayland
+}:
 
 let
-  minorVersion = "2.3";
-  version = "${minorVersion}.15";
-  OpenColorIO-Configs = fetchurl {
-    url = "https://github.com/NatronGitHub/OpenColorIO-Configs/archive/Natron-v${minorVersion}.tar.gz";
-    sha256 = "AZK9J+RnMyxOYcAQOAQZj5QciPQ999m6jrtBt5rdpkA=";
+  minorVersion = "2.5";
+  version = "${minorVersion}.0";
+  OpenColorIO-Configs = fetchFromGitHub {
+    owner = "NatronGitHub";
+    repo = "OpenColorIO-Configs";
+    rev = "Natron-v${minorVersion}";
+    hash = "sha256-TD7Uge9kKbFxOmOCn+TSQovnKTmFS3uERTu5lmZFHbc=";
   };
-  seexpr = stdenv.mkDerivation rec {
-    version = "1.0.1";
-    pname = "seexpr";
-    src = fetchurl {
-      url = "https://github.com/wdas/SeExpr/archive/rel-${version}.tar.gz";
-      sha256 = "1ackh0xs4ip7mk34bam8zd4qdymkdk0dgv8x0f2mf6gbyzzyh7lp";
-    };
-    nativeBuildInputs = [ cmake ];
-    buildInputs = [ libpng flex bison ];
-  };
-  buildPlugin = { pluginName, sha256, nativeBuildInputs ? [], buildInputs ? [], preConfigure ? "", postPatch ? "" }:
-    stdenv.mkDerivation {
-      pname = "openfx-${pluginName}";
-      version = version;
-      src = fetchurl {
-        url = "https://github.com/NatronGitHub/openfx-${pluginName}/releases/download/Natron-${version}/openfx-${pluginName}-Natron-${version}.tar.xz";
-        inherit sha256;
-      };
-      inherit nativeBuildInputs buildInputs postPatch;
-      preConfigure = ''
-        makeFlagsArray+=("CONFIG=release")
-        makeFlagsArray+=("PLUGINPATH=$out/Plugins/OFX/Natron")
-        ${preConfigure}
-      '';
-    };
-  lodepngcpp = fetchurl {
-    url = "https://raw.githubusercontent.com/lvandeve/lodepng/a70c086077c0eaecbae3845e4da4424de5f43361/lodepng.cpp";
-    sha256 = "1dxkkr4jbmvlwfr7m16i1mgcj1pqxg9s1a7y3aavs9rrk0ki8ys2";
-  };
-  lodepngh = fetchurl {
-    url = "https://raw.githubusercontent.com/lvandeve/lodepng/a70c086077c0eaecbae3845e4da4424de5f43361/lodepng.h";
-    sha256 = "14drdikd0vws3wwpyqq7zzm5z3kg98svv4q4w0hr45q6zh6hs0bq";
-  };
-  cimgversion = "89b9d062ec472df3d33989e6d5d2a8b50ba0775c";
-  CImgh = fetchurl {
-    url = "https://raw.githubusercontent.com/dtschump/CImg/${cimgversion}/CImg.h";
-    sha256 = "sha256-NbYpZDNj2oZ+wqoEkRwwCjiujdr+iGOLA0Pa0Ynso6U=";
-  };
-  inpainth = fetchurl {
-    url = "https://raw.githubusercontent.com/dtschump/CImg/${cimgversion}/plugins/inpaint.h";
-    sha256 = "sha256-cd28a3VOs5002GkthHkbIUrxZfKuGhqIYO4Oxe/2HIQ=";
-  };
-  plugins = map buildPlugin [
-    ({
-      pluginName = "arena";
-      sha256 = "tUb6myG03mRieUAfgRZfv5Ap+cLvbpNrLMYCGTiAq8c=";
-      nativeBuildInputs = [ pkg-config ];
-      buildInputs = [
-        pango librsvg librevenge libcdr opencolorio_1 libxml2 libzip
-        poppler imagemagick
-      ];
-      preConfigure = ''
-        sed -i 's|pkg-config poppler-glib|pkg-config poppler poppler-glib|g' Makefile.master
-        for i in Extra Bundle; do
-          cp ${lodepngcpp} $i/lodepng.cpp
-          cp ${lodepngh} $i/lodepng.h
-        done
-      '';
-    })
-    ({
-      pluginName = "io";
-      sha256 = "OQg6a5wNy9TFFySjmgd1subvXRxY/ZnSOCkaoUo+ZaA=";
-      nativeBuildInputs = [ pkg-config ];
-      buildInputs = [
-        libpng ffmpeg openexr opencolorio_1 openimageio_1 boost libGL
-        seexpr libraw openjpeg libwebp
-      ];
-    })
-    ({
-      pluginName = "misc";
-      sha256 = "XkdQyWI9ilF6IoP3yuHulNUZRPLX1m4lq/+RbXsrFEQ=";
-      buildInputs = [
-        libGL
-      ];
-      postPatch = ''
-        cp '${inpainth}' CImg/Inpaint/inpaint.h
-        patch -p0 -dCImg < CImg/Inpaint/inpaint.h.patch # taken from the Makefile; it gets skipped if the file already exists
-        cp '${CImgh}' CImg/CImg.h
-      '';
-    })
-  ];
 in
 stdenv.mkDerivation {
   inherit version;
@@ -101,28 +34,40 @@ stdenv.mkDerivation {
     repo = "Natron";
     rev = "v${version}";
     fetchSubmodules = true;
-    sha256 = "sha256-KuXJmmIsvwl4uqmAxXqWU+273jsdWrCuUSwWn5vuu8M=";
+    hash = "sha256-dgScbfyulZPlrngqSw7xwipldoRd8uFO8VP9mlJyhQ8=";
   };
 
-  nativeBuildInputs = [ qmake4Hook pkg-config python2Packages.wrapPython ];
+  cmakeFlags = [ "-DNATRON_SYSTEM_LIBS=ON" ];
 
-  buildInputs = [
-    qt4 boost expat cairo python2Packages.pyside python2Packages.pysideShiboken
+  nativeBuildInputs = [
+    cmake
+    pkg-config
+    wrapQtAppsHook
   ];
 
-  preConfigure = ''
-    export MAKEFLAGS=-j$NIX_BUILD_CORES
-    cp ${./config.pri} config.pri
-    mkdir OpenColorIO-Configs
-    tar -xf ${OpenColorIO-Configs} --strip-components=1 -C OpenColorIO-Configs
+  buildInputs = [
+    boost
+    expat
+    cairo
+    python3
+    python3.pkgs.pyside2
+    python3.pkgs.shiboken2
+    extra-cmake-modules
+    wayland
+    glog
+    ceres-solver
+    libXdmcp
+  ];
+
+  postInstall = ''
+    mkdir -p $out/share
+    cp -r ${OpenColorIO-Configs} $out/share/OpenColorIO-Configs
   '';
 
   postFixup = ''
-    for i in ${lib.escapeShellArgs plugins}; do
-      ${lndir}/bin/lndir $i $out
-    done
     wrapProgram $out/bin/Natron \
-      --set PYTHONPATH "$PYTHONPATH"
+      --prefix PYTHONPATH : "${python3.pkgs.makePythonPath [ python3.pkgs.qtpy python3.pkgs.pyside2 ]}" \
+      --set-default OCIO "$out/share/OpenColorIO-Configs/blender/config.ocio"
   '';
 
   meta = with lib; {
@@ -135,6 +80,6 @@ stdenv.mkDerivation {
     license = lib.licenses.gpl2;
     maintainers = [ maintainers.puffnfresh ];
     platforms = platforms.linux;
-    broken = true; # Last evaluated on Hydra on 2021-05-18
+    broken = stdenv.isLinux && stdenv.isAarch64;
   };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 14baad9464aa..24cdb416b717 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -32972,7 +32972,7 @@ with pkgs;
 
   neomutt = callPackage ../applications/networking/mailreaders/neomutt { };
 
-  natron = callPackage ../applications/video/natron { };
+  natron = libsForQt5.callPackage ../applications/video/natron { };
 
   natural-docs = callPackage ../applications/misc/natural-docs { };