diff --git a/pkgs/applications/misc/zathura/core/default.nix b/pkgs/applications/misc/zathura/core/default.nix
index f3258c0c7116..6378cf1c0681 100644
--- a/pkgs/applications/misc/zathura/core/default.nix
+++ b/pkgs/applications/misc/zathura/core/default.nix
@@ -32,15 +32,15 @@ stdenv.mkDerivation rec {
   ] ++ optional synctexSupport "-Dsynctex=enabled";
 
   nativeBuildInputs = [
-    meson ninja pkgconfig appstream-glib desktop-file-utils python3.pkgs.sphinx
+    meson ninja pkgconfig desktop-file-utils python3.pkgs.sphinx
     gettext makeWrapper libxml2
-  ];
+  ] ++ optional stdenv.isLinux appstream-glib;
 
   buildInputs = [
-    gtk girara libintl libseccomp
-    sqlite glib file librsvg
+    gtk girara libintl sqlite glib file librsvg
   ] ++ optional synctexSupport texlive.bin.core
-    ++ optional stdenv.isDarwin [ gtk-mac-integration ];
+    ++ optional stdenv.isLinux libseccomp
+    ++ optional stdenv.isDarwin gtk-mac-integration;
 
   meta = {
     homepage = https://pwmt.org/projects/zathura/;
diff --git a/pkgs/applications/misc/zathura/default.nix b/pkgs/applications/misc/zathura/default.nix
index dfddfe7d91e1..e3db15ca78d4 100644
--- a/pkgs/applications/misc/zathura/default.nix
+++ b/pkgs/applications/misc/zathura/default.nix
@@ -1,5 +1,6 @@
 { config, pkgs
-, useMupdf ? config.zathura.useMupdf or true
+# zathura_pdf_mupdf fails to load _opj_create_decompress at runtime on Darwin (https://github.com/NixOS/nixpkgs/pull/61295#issue-277982980)
+, useMupdf ? config.zathura.useMupdf or (!pkgs.stdenv.isDarwin)
 , synctexSupport ? true }:
 
 let
diff --git a/pkgs/applications/misc/zathura/pdf-mupdf/default.nix b/pkgs/applications/misc/zathura/pdf-mupdf/default.nix
index 709c1edb0b83..e2c08a00da20 100644
--- a/pkgs/applications/misc/zathura/pdf-mupdf/default.nix
+++ b/pkgs/applications/misc/zathura/pdf-mupdf/default.nix
@@ -21,9 +21,7 @@ stdenv.mkDerivation rec {
 
   buildInputs = [
     zathura_core girara mupdf cairo
-  ] ++ stdenv.lib.optional stdenv.isDarwin [
-    gtk-mac-integration
-  ];
+  ] ++ lib.optional stdenv.isDarwin gtk-mac-integration;
 
   PKG_CONFIG_ZATHURA_PLUGINDIR= "lib/zathura";