diff --git a/pkgs/tools/misc/picocom/default.nix b/pkgs/tools/misc/picocom/default.nix
index bb66b97039da..c49695fd9ad9 100644
--- a/pkgs/tools/misc/picocom/default.nix
+++ b/pkgs/tools/misc/picocom/default.nix
@@ -1,4 +1,8 @@
-{ stdenv, fetchFromGitHub, makeWrapper, lrzsz }:
+{ stdenv, fetchFromGitHub, makeWrapper, lrzsz, IOKit }:
+
+assert stdenv.isDarwin -> IOKit != null;
+
+with stdenv.lib;
 
 stdenv.mkDerivation rec {
   name = "picocom-${version}";
@@ -11,7 +15,8 @@ stdenv.mkDerivation rec {
     sha256 = "1vvjydqf0ax47nvdyyl67jafw5b3sfsav00xid6qpgia1gs2r72n";
   };
 
-  buildInputs = [ makeWrapper ];
+  buildInputs = [ makeWrapper ]
+    ++ optionals stdenv.isDarwin [ IOKit ];
 
   installPhase = ''
     mkdir -p $out/bin $out/share/man/man1
@@ -26,6 +31,6 @@ stdenv.mkDerivation rec {
     description = "Minimal dumb-terminal emulation program";
     homepage = https://github.com/npat-efault/picocom/;
     license = stdenv.lib.licenses.gpl2Plus;
-    platforms = stdenv.lib.platforms.gnu ++ stdenv.lib.platforms.linux;  # arbitrary choice
+    platforms = platforms.unix;
   };
 }
diff --git a/pkgs/top-level/all-packages.nix b/pkgs/top-level/all-packages.nix
index 35d986a10d49..80e9680cb1b8 100644
--- a/pkgs/top-level/all-packages.nix
+++ b/pkgs/top-level/all-packages.nix
@@ -18821,7 +18821,9 @@ in
 
   picard = callPackage ../applications/audio/picard { };
 
-  picocom = callPackage ../tools/misc/picocom { };
+  picocom = callPackage ../tools/misc/picocom {
+    inherit (darwin.apple_sdk.frameworks) IOKit;
+  };
 
   pidgin = callPackage ../applications/networking/instant-messengers/pidgin {
     openssl = if config.pidgin.openssl or true then openssl else null;