diff --git a/pkgs/tools/package-management/nix/default.nix b/pkgs/tools/package-management/nix/default.nix
index a7eca679780d..7c5973190711 100644
--- a/pkgs/tools/package-management/nix/default.nix
+++ b/pkgs/tools/package-management/nix/default.nix
@@ -119,7 +119,8 @@ common =
            # RISC-V support in progress https://github.com/seccomp/libseccomp/pull/50
         ++ lib.optional (!withLibseccomp) "--disable-seccomp-sandboxing";
 
-      makeFlags = [ "profiledir=$(out)/etc/profile.d" ];
+      makeFlags = [ "profiledir=$(out)/etc/profile.d" ]
+        ++ lib.optional (stdenv.hostPlatform != stdenv.buildPlatform) "PRECOMPILE_HEADERS=0";
 
       installFlags = [ "sysconfdir=$(out)/etc" ];